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Safford is the principal city of the Safford Micropolitan Statistical Area, which includes all of Graham and Greenlee counties.
Safford is located at (32.823266, -109.714613). The Pinaleno Mountains sit prominently to the southwest of town. The Pinalenos have the greatest vertical relief of any mountain range in Arizona.
According to the United States Census Bureau, the city has a total area of 7.9 square miles (20.6 km²), of which, 7.9 square miles (20.5 km²) of it is land and 0.04 square miles (0.1 km²) of it (0.38%) is water.