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(the Spanish language name of Saint Louis) is a city in Yuma County, Arizona, United States. The population was 15,322 at the 2000 census. It is part of the Yuma Metropolitan Statistical Area. San Luis was the second fastest-growing place among all cities and towns in Arizona of any size from 1990 and 2000. According to 2006 Census Bureau estimates, the population of the city is 22,634.
The City of San Luis is located in the southwestern end of the state of Arizona, comprises part of an important industrial, agricultural and commercial area together along with San Luis Río Colorado, Sonora, a zone considered to offer great advantages for the commercial trade between the United States and Mexico.
The city was established in 1930 with the opening of a border crossing station. In the last twenty years it has registered an accelerated population increase, going from 1,946 inhabitants in 1980, to approximately 20,000 in the year 2000. The growth is due to a constant migration from Mexico and California, productive activities in the border area and opportunities San Luis has to offer. The City has annexed over of land within the past six years, thereby increasing the availability of land for residential, commercial and industrial growth in the eastern part of town where the new commercial port of entry will be constructed.