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) is a city in California, located roughly midway between San Francisco and Los Angeles on the Central Coast. The city, referred to locally as "SLO" or "San Luis", is the county seat of San Luis Obispo County and is adjacent to California Polytechnic State University (Cal Poly). As of the 2006 Census Bureau estimate, the city population was 42,963 (down 2.8% from 2000).
Earliest human inhabitants of the local area were the Chumash peoples, who settled in the vicinity circa 5000 to 10000 years BC. One of the earliest villages lies south of San Luis Obispo, and reflects the landscape of the early Holocene when estuaries came farther inland and sea levels were higher. These Chumash people exploited marine resources of the inlets and bays along the Central Coast and inhabited a network of villages including sites at Los Osos and Morro Creek.
The City of San Luis Obispo serves as the commercial, governmental, and cultural hub of San Luis Obispo County. One of California’s oldest communities, it began with the founding of Mission San Luis Obispo de Tolosa in 1772 by Father Junípero Serra, on the site of a Chumash village called Tilhini, as the fifth Spanish mission in California's chain of 21 missions. The mission was named after Saint Louis, a thirteenth century bishop of Toulouse, France. It is one of the best preserved examples of Spanish Mission architecture and among the oldest buildings in California.
San Luis Obispo once had a burgeoning Chinatown in the vicinity of Palm St. and Chorro St. Laborers were brought from China by Ah Louis in order to construct the Pacific Coast Railway, roads connecting San Luis Obispo to Paso Robles and Paso Robles to Cambria, and also the 1884 to 1894 tunneling through Cuesta Ridge for the Southern Pacific Railroad. SLO's Chinatown revolved around Ah Louis Store and other Palm Street businesses owned and run by Chinese business people. Today, Mee Heng Low chop suey shop is all that remains of the culture, although a revitalized Chinatown development is being planned. A display of some of the unearthed relics from this period can be seen on the first floor of the Palm Street parking garage, which was built over the location where Chinatown once stood. The San Luis Obispo Historical Society (adjacent to the Mission) also contains rotating historical exhibits.
San Luis Obispo was also a popular stop on both U.S. Route 101 and California State Route 1 with the rise of car culture. Due to its popularity as a stop, it was the location of the nation's first motel, the Milestone Mo-Tel.