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is a town in New London County, Connecticut, United States. The population was 2,016 at the 2000 census. Lyme and its neighboring town Old Lyme are the namesake for Lyme disease.
According to the United States Census Bureau, the town has a total area of 34.5 square miles (89.3 km²), of which, 31.9 square miles (82.5 km²) of it is land and 2.6 square miles (6.8 km²) of it (7.63%) is water.