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() is a city in the southeastern part of the U.S. state of Iowa and one of the county seats of Lee County. The other county seat is Fort Madison. The population was 11,427 at the 2000 census. The city is named after Sauk Chief Keokuk, who is buried in Rand Park. It is located in the extreme southeast corner of Iowa where the Des Moines River meets with the Mississippi. It is located at the junction of U.S. Routes 61, 136 and 218. Just across the rivers are the small towns of Hamilton and Warsaw, Illinois, and Alexandria, Missouri.
Keokuk along with the city of Fort Madison, are principal cities of the Fort Madison–Keokuk Micropolitan Statistical Area, which includes all of Lee County, Iowa and Clark County, Missouri.
Keokuk is located at (40.402525, -91.394372).
According to the United States Census Bureau, the city has a total area of 10.6 square miles (27.4 km²), of which, 9.2 square miles (23.7 km²) of it is land and 1.4 square miles (3.7 km²) of it (13.42%) is water.