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is a city in Louisa County, Iowa, United States. The population was 2,124 at the 2000 census. It is the county seat of Louisa County. It is pronounced whop-UH-low, and almost rhymes with Tupelo.
According to the United States Census Bureau, the city has a total area of 1.3 square miles (3.4 km²), of which, 1.3 square miles (3.3 km²) of it is land and 0.1 square miles (0.1 km²) of it (3.85%) is water. Wapello is on the Iowa River.