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is a city in Madison County, Illinois, United States. The population was 11,296 at the 2000 census.
According to the United States Census Bureau, the city has a total area of 6.1 square miles (15.7 km²), of which, 6.1 square miles (15.7 km²) of it is land and 0.04 square miles (0.1 km²) of it (0.33%) is water.
Wood River is located on the Mississippi River approximately upstream of downtown St. Louis, Missouri among several coterminus cities and villages that have come to be known as the "Riverbend" area. The current confluence of the Mississippi and the Missouri Rivers is just south of one of these neighboring villages, Hartford. Other cities making up the "Riverbend" include Alton, East Alton, Godfrey, Roxana and Bethalto.