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is a city in and the parish seat of Iberville Parish, Louisiana, United States. The population was 7,064 at the 2000 census. It is part of the Baton Rouge Metropolitan Statistical Area.
Plaquemine is the birthplace of radio talk show host Moon Griffon, who broadcasts statewide from Monroe. Griffon is sometimes know as the "Cajun Rush Limbaugh".
The town is also home to former Democratic Lieutenant Governor Robert "Bobby" Freeman.
Plaquemine is located at (30.284044, -91.240485) and has an elevation of . Plaqumeine is located at the junction of Bayou Plaqumeine and The Mississippi River. The city itself is surrounded by farmland. Beyond the farmand on its western sides lies nearly uninhabited swampland.
According to the United States Census Bureau, the city has a total area of 2.9 square miles (7.6 km²), of which, 2.9 square miles (7.4 km²) of it is land and 0.1 square miles (0.1 km²) of it (1.71%) is water.