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is a town in Worcester County, Massachusetts, United States. The population was 5,286 at the 2000 census.
Mendon is very historic and is now part of the Blackstone River Valley National Heritage Corridor, the oldest industrialized region in the United States.
According to the United States Census Bureau, the town has a total area of 18.3 square miles (47.3 km²), of which, 18.1 square miles (46.9 km²) of it is land and 0.2 square miles (0.4 km²) of it (0.88%) is water.