is a town in Somerset County, Maryland, United States. The population was 2,313 at the 2000 census. It is the county seat of Somerset County.
Princess Anne is included in the Salisbury, Maryland Metropolitan Statistical Area.
The town is notable as the location of the University of Maryland Eastern Shore.
With a population just under 2400 people, this hamlet at the head of the Manokin River was named for Princess Anne of Great Britain, daughter of King George II. It was established in 1733 and serves as the county seat for Somerset County (the southernmost county in Maryland).
In the mid-18th century, Princess Anne gained considerable importance as a market center because of the river trade. This was later augmented by the southward extension of the railroad on Maryland's Eastern Shore. At that time, the Manokin River was navigable as far as the bridge at Princess Anne.
Much of the town's architectural heritage from those days has been preserved. About 150 acres (0.6 km²) of the old town, containing about 300 structures, is entered on the National Register of Historic Places as the Princess Anne Historic District.