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( or ) is a city in southeastern Maryland, United States. It is the county seat of Wicomico County, Maryland and the largest city in Maryland's Eastern Shore region. The city's population was 23,743 at the 2000 census. Salisbury is the principal city of the Salisbury, Maryland Metropolitan Statistical Area, which is part of the Salisbury-Ocean Pines, Maryland Combined Statistical Area. The city is the commercial hub of the Delmarva Peninsula and is sometimes called "the Crossroads of Delmarva".
Salisbury's location at the head of Wicomico River was a major factor in growth. At first it was a small colonial outpost of Lord Baltimore's. The river was the only navigable waterway leading out to the Chesapeake Bay for early settlers. In 1732, Salisbury became an official port, growing to be second only to Baltimore as the most active seaport in Maryland.
Salisbury is located near several major cities: Baltimore ; Washington, D.C. , Philadelphia , Norfolk , Dover , and Wilmington .
According to the United States Census Bureau, the city has a total area of 11.4 square miles (29.6 km²), of which, 11.1 square miles (28.7 km²) of it is land and 0.4 square miles (0.9 km²) of it (3.15%) is water. The city has varying elevation of 17 – 45 ft.