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is the largest city in Pearl River County in Mississippi, a state of the United States of America. The population according to the 2007 census estimate was 11,591. Picayune, with a population of about 30,000 is the business and medical center of Pearl River County. Picayune is located approximately from New Orleans, Hattiesburg, and Gulfport/Biloxi. The Stennis Space Center is away.
According to the United States Census Bureau, the city has a total area of 11.8 square miles (30.6 km²), of which, 11.8 square miles (30.5 km²) of it is land and 0.04 square miles (0.1 km²) of it (0.34%) is water.