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was an early settlement in the U.S. state of Mississippi in present-day Lowndes County.
Plymouth was located at on the west bank of the Tombigbee River. Today, the site is close to present-day Columbus and just west of John C. Stennis Lock and Dam on the Tennessee-Tombigbee Waterway.
is located nearby at . Plymouth Bluff is the site of the
, operated by the Mississippi University for Women, but on land owned by the Army Corps of Engineers.