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is a city in Tippah County, Mississippi, United States. The population was 5,478 at the 2000 census. It is the county seat of Tippah County.
Colonel William Clark Falkner, great-grandfather of authors William Faulkner and John Faulkner, was a prominent resident of Ripley in the mid to late-19th century. W.C. Falkner's exploits in and around Ripley served as the model for Faulkner's character of Colonel John Sartoris.
According to the United States Census Bureau, the city has a total area of 11.5 square miles (29.9 km²), of which, 11.5 square miles (29.8 km²) of it is land and 0.04 square miles (0.1 km²) of it (0.35%) is water.