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is a city in Keith County, Nebraska, United States. The population was 4,930 at the 2000 census. It is the county seat of Keith County. In the days of the Nebraska Territory, the city was a stop on the Pony Express and later along the transcontinental railroad. The Ogallala Aquifer was named after the city.
Ogallala first gained fame as a terminus for cattle drives that traveled from Texas to the Union Pacific railhead located there. These trails are known as the Western or Great Western trails. The Union Pacific Railroad reached Ogallala on May 24, 1867.