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is a village in Erie County, New York, United States. The population was 16,629 at the 2000 census. It is part of the Buffalo–Niagara Falls Metropolitan Statistical Area. The name is derived from Chauncey Mitchell Depew, the President of the New York Central Railroad and former US Senator.
village extends across the boundary between the towns of Lancaster and Cheektowaga. The village lies on both sides of NY Route 78 (Transit Road), a major north-south route.
The site of the future village was settled in 1808. Named after "Railman" Chauncey Depew, the Village was founded as it become a hub of rapid growth. Founded in 1892 as a rail center, the Village of Depew was incorporated on July 23, 1894. The Depew economy in the 19th century was based primarily on railroad-related industries.
Depew also has a long-standing rivalry between themselves and Lancaster High School. This rivalry started back in 1919. The rivalry between has been strong and it is still a great battle between the smaller school versus the larger school despite the fact that Lancaster has won a majority of the games between the two rivals.
The poet Lucille Clifton was born and raised in Depew. She learned as a child to speak Polish as well as English.