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is a village in Madison and Union counties in the U.S. state of Ohio. The population was 2,832 at the 2000 census.
Until about 1800, the Ohio Country was inhabited by Mingo and Wyandot indians, and there was an Indian village just north of present-day Plain City. After 1795, as white settlers began moving into the region, the area around present-day Plain City was referred to as Pleasant Valley. In 1814, Isaac Bigelow travelled to the area from Center County, Pennsylvania to pay for land purchased from his uncle. He then returned to Pennsylvania to study medicine with his father. Bigelow returned to Ohio in 1817, and to the Pleasent Valley area in 1818. He hired a surveyor named David Chapman, and laid out the town of Westminster. At the time, Westminster lay wholly within Madison County. In 1820, when Union County was formed, the county line was moved to the middle of Westminster. In 1823, additional territory was incorporated, and the town's name was changed to Pleasant Valley. Due to there already being another town in Ohio named Pleasant Valley, the town changed its name Plain City.
Plain City and the surrounding area have a strong German and agricultural heritage. Plain City was a stop along the Pittsburgh, Cincinnati, Chicago and St. Louis Railroad that connected Pittsburgh to Chicago and St. Louis.