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is a village in Logan County, Ohio, United States of America. The population was 220 at the 2000 census. It is the smallest incorporated village in Logan County.
Zanesfield is named for Isaac Zane, who was born in 1753 in what was then Berkeley County, Virginia, and is now Hardy County, West Virginia. He was the youngest brother of Ebenezer Zane, for whom Zanesville, Ohio, is named.
In 1762 at the age of nine, Isaac was captured by Native Americans of the Wyandot tribe and adopted into the tribe. He lived with them along the Sandusky River for seventeen years. He married
. They had several children.
His Wyandot connections and bilingual abilities served Zane well. He later served as a guide to the Commissioners of the Northwest Territory during their treaty conferences with the Native Americans. In return for this service, in 1795 the United States Congress granted Isaac Zane a tract of along the Mad River in present-day Logan County, Ohio. In 1803, he was elected as one of the first trustees of Jefferson Township. Isaac Zane died in 1816, and was buried near Zanesfield.