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is a city in and the county seat of Muskingum County, Ohio, United States. The population was 25,586 at the 2000 census.
Zanesville was named after Ebenezer Zane, who settled there in 1797 with his son-in-law, John McIntire, at the point where Zane's Trace met the Muskingum River. The city was the second state capital of Ohio from 1810 to 1812. The National Road runs through Zanesville as U.S. Route 40. Novelist Zane Grey was a descendant of the Zane family and was born in the city.
Zanesville is located at (39.946049, -82.012150), along the Muskingum River at its confluence with the Licking River.
According to the United States Census Bureau, the city has a total area of 29.8 km² (11.5 sq mi). 11.2 square miles (29.1 km²) of it is land and 0.3 square miles (0.7 km²) of it (2.26%) is water.
The area has important deposits of clay which were exploited by a number of pottery companies in the first half of the twentieth century. Famous companies included the Roseville pottery and the American Encaustic Tiling Co.