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is a city in Lincoln County, Oregon, United States, located on U.S. Route 101 next to the Pacific Ocean. The population was 1,174 at the 2000 census, with an unofficial estimated population of 1,355 in 2007. The bay of the same name is a six-acre (24,000 m²) harbor that the city promotes as the world's smallest.
Depoe Bay was founded by Siletz Indian "Charley" Depot (whose name was later changed to "DePoe"). His original tribal affiliation was Tututni.