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is an unincorporated village in Peach Bottom Township, Lancaster County, in the state of Pennsylvania in the United States. It lies on the east bank of the Susquehanna River, at .
The original town of Peach Bottom was located across the river in York County. With the construction of the Columbia and Port Deposit Railroad up the east side of the Susquehanna, a station was built on the Lancaster County side, near the mouth of Peters Creek, from which Peach Bottom could be reached by ferry. This was known as Peach Bottom Station.
The Peach Bottom Railway had termini at both Peach Bottom and Peach Bottom Station; a planned bridge to connect them was never built. The line on the east side became the Lancaster, Oxford and Southern Railroad and on the west side, the Maryland and Pennsylvania Railroad.
When the Conowingo Dam was built, the Columbia and Port Deposit was relocated higher up the hillside, and both Peach Bottom and Peach Bottom Station were submerged. The present village was built a short distance southeast of the site of Peach Bottom Station.
It is the site of a post office (zip code 17563). The Peach Bottom Nuclear Generating Station lies across the river, on the site of the original town.