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( or ) is a city in Northeastern Pennsylvania, United States. It is the county seat of Luzerne County and the central city of the Wyoming Valley. Founded in 1769 and formally incorporated in 1806, the city has an estimated population of 43,123, according to the 2000 census. Wilkes-Barre is also one of the core cities of the Scranton-Wilkes Barre, Pennsylvania Metropolitan Statistical Area which has an estimated 2007 population of 549,430.
Wilkes-Barre and surrounding Wyoming Valley are framed by the Pocono Mountains to the east, the Endless Mountains to the west and the Lehigh Valley to the south. The Susquehanna River flows through the center of the valley and defines the northwestern border of the city.
As of the census of 2000, there were 43,123 people, 17,961 households, and 9,878 families residing in the city. The population density was 6,296.3 people per square mile (2,430.6/km²). There were 20,294 housing units at an average density of 2,963.1/sq mi (1,143.9/km²). The racial makeup of the city was 92.30% White, 5.09% African American, 0.11% Native American, 0.79% Asian, 0.03% Pacific Islander, 0.53% from other races, and 1.15% from two or more races. Hispanic or Latino of any race were 1.58% of the population.
In the city the population was spread out with 19.9% under the age of 18, 12.6% from 18 to 24, 26.1% from 25 to 44, 20.8% from 45 to 64, and 20.6% who were 65 years of age or older. The median age was 39 years. For every 100 females there were 93.2 males. For every 100 females age 18 and over, there were 90.7 males.