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, formerly called Pickens Courthouse, is a city in Pickens County, South Carolina, United States. The population was 3,012 at the 2000 census, at which time it was listed as a town; the change to a city was made in 1998, but not reported to the Census Bureau until 2001. It is the county seat of Pickens County. It was named after Andrew Pickens (1739–1817), an American revolutionary soldier and US Congressman for South Carolina.
Pickens is part of the Greenville–Mauldin–Easley Metropolitan Statistical Area.
According to the United States Census Bureau, the town had a total area of 2.5 square miles (6.4 km²), of which, 2.5 square miles (6.3 km²) of it is land and 0.04 square miles (0.1 km²) of it (0.81%) is water.