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is a town in Pocahontas County, West Virginia, United States. The population was 243 at the 2000 census.
Hillsboro was named for pioneer John (Richard) Hill, from North Carolina, who built a log cabin near what is now Lobelia. Most of the early settlers were Scotch-Irish and worked in agriculture and stock raising.
Millpoint, in northern Hillsboro, was once the site of a small industrial village, "including within its limits proper a store, a blacksmith shop, two flour mills, and three homes." One of the mills has been restored and can be seen along Rt. 219.
In 1892, famous author Pearl S. Buck was born in a large white two-story house at the northern end of town. Shortly thereafter, her family, Presbyterian missionaries, returned to China, but her West Virginia roots nevertheless had a significant impact on Pearl through her mother Carrie. The house, now on the National Register of Historic Places, has been restored into a museum, The Pearl S. Buck Birthplace.